lost control over our house lights

so the other week we turned on our board to put new gels into lights and when we went to our pre-show cue we didn't have any lights on. The issue is only with our house lights. I can still control most of our other lights other then our Mac 250s. we tried saving the show and reloading, turning off the dimmers and cleaning them out and the issue is still not fixed. I know the grand master is on full and black out is not on. We do not appear to have any issues in our patching. Does anyone have an idea what might be going on?