MSC- firing Isadora

Hello,  having issues with MSC. I have a Ion on 3.1 software, a mac computer running Isadora, and a ‘fast lane usb’ MOTU. I would like the Ion to fire Isadora cues.  At the moment we can’t get the two to talk. 
I’m not sure what the settings on the Ion or Isadora should be, or if theres something about our setup that is wrong. 
Any help would be appreciated!